Disease Areas

Patients with AS may experience stiffness and significant pain in the lower back and sacroiliac joints.^4,5 Inflammatory back pain in AS generally worsens during periods of inactivity, especially at night, which can make it difficult for many patients to sleep well.

Patients with CD can experience diarrhea, fever, nausea, abdominal pain, and severe weight loss.¹ Chronic intestinal inflammation leads to progressive and destructive disease associated with damage to the mucosa.³ Over time, patients may develop stricturing or penetrating complications of disease, and more than 50% of individuals with CD require surgery within 10 years of diagnosis.^4,5 The symptoms of CD may also result in significant anxiety, stress, depression, and isolation.^1,6 Although CD does not significantly shorten life expectancy, patient

Patients with nr-axSpA may experience chronic lower back pain and inflammation of the sacroiliac joints.^5,6 Additionally, lack of sleep and fatigue are commonly reported by these patients.⁷ Extra-spinal manifestations of disease, including uveitis, psoriasis, inflammatory bowel disease, dactylitis, peripheral arthritis, and enthesitis may also occur.^7,8 Symptoms of nr-axSpA can have a significant impact on patients’ function, with patients experiencing reduced ability to work and lower work productivity.⁹ Patients may also experience anxiety, depr

PSO is characterized by well-defined, raised plaques with silvery scales.^2,3 The plaques commonly occur on the scalp; extensor surfaces such as the elbows and knees; and the lower back.  Nail involvement is also common.²

In addition to inflammation, swelling, and pain in the joints, patients with PsA may experience extra-articular manifestations, including enthesitis, dactylitis, uveitis, and inflammatory bowel disease.⁴ Importantly, PsA occurs in up to 30% of patients with psoriasis, and in 85% of patients, skin disease (ie, psoriasis) occurs before joint disease.⁵ If left untreated, PsA may result in persistent pain and inflammation, permanent joint damage, and disability.^4,6 PsA is associated with a substantial disease burden negatively affecting physical function as well

Although some patients may experience a mild illness with minimal joint damage, in most patients with uncontrolled disease activity, RA will follow a progressive course, leading to increasing degrees of joint destruction, pain, and functional decline.¹ Patients may also experience fatigue, weight loss, and extra-articular involvement.^1,4,5 These patients tend to be less productive at work or experience such severe symptoms that they are unable to work at all.⁵