Publications

Publications

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This page contains links to basic science and clinical research published on UCB medicines and disease areas of focus. The information is limited to products that have been approved for use by the U.S. Food and Drug Administration (FDA) and may contain information that is not part of the FDA-approved Prescribing Information (eg, doses, uses, devices, populations). UCB, Inc. does not recommend or endorse the use of its products in a manner not consistent with the approved Prescribing Information. Please see the Full Prescribing Information for each product when making clinical decisions.
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phase 4

CIMZIA® (certolizumab pegol)

Women's Health

Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study. 

Mariette X, Förger F, Abraham B et al. 2018
phase 3

CIMZIA® (certolizumab pegol)

Psoriatic Arthritis

4-year results from the RAPID-PsA phase 3 randomised placebo-controlled trial of certolizumab pegol in psoriatic arthritis. 

van der Heijde D, Deodhar A, FitzGerald O et al. 2018
phase 3

CIMZIA® (certolizumab pegol)

Plaque Psoriasis

Certolizumab pegol for the treatment of chronic plaque psoriasis: results through 48 weeks from two phase 3, multicenter, randomized, double-blinded, placebo-controlled studies (CIMPASI-1 and CIMPASI-2). 

Gottlieb A, Blauvelt A, Diamant T et al. 2018
pre clinical

RYSTIGGO® (rozanolixizumab-noli)

Generalized Myasthenia
 Gravis

Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration

Smith Bryan, Kiessling Andrea, Lledo-Garcia Rocio et al. October 2018
phase 2

BIMZELX® (bimekizumab-bkzx)

Plaque Psoriasis

Dual neutralization of both interleukin 17A and interleukin 17F with bimekizumab in patients with psoriasis: Results from BE ABLE 1, a 12-week randomized, double-blinded, placebo-controlled phase 2b trial.

Krueger James, Feldman Steven, Umezawa Yoshinori et al. March 2018
phase 3

CIMZIA® (certolizumab pegol)

Ankylosing Spondylitis, Non-radiographic Axial Spondyloarthritis

Limited radiographic progression and sustained reductions in MRI inflammation in patients with axial spondyloarthritis: 4-year imaging outcomes from the RAPID-axSpA phase III randomised trial. 

van der Heijde D, Baraliakos X, Hermann K-G et al. 2018
phase 3

CIMZIA® (certolizumab pegol)

Plaque Psoriasis

Certolizumab pegol for the treatment of chronic plaque psoriasis: Results through 48 weeks of a phase 3, multicenter, randomized, double-blind, etanercept- and placebo-controlled study. 

Lebwohl M, Blauvelt A, Paul C et al. 2018
phase 1

RYSTIGGO® (rozanolixizumab-noli)

Generalized Myasthenia
 Gravis

The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study

Kiessling Peter, Lledo-Garcia Rocio, Watanabe Shikiko et al. November 2017
phase 3

CIMZIA® (certolizumab pegol)

Rheumatoid Arthritis

The first study of certolizumab pegol in combination with methotrexate in DMARD-naïve early rheumatoid arthritis patients led to sustained clinical response and inhibition of radiographic progression at 52 weeks: the C-EARLY randomized, double-blind, controlled phase 3 study. 

Emery P, Bingham CO, Burmester GR et al. 2017
phase 3

CIMZIA® (certolizumab pegol)

Ankylosing Spondylitis, Non-radiographic Axial Spondyloarthritis

Effect of certolizumab pegol over 96 weeks of treatment on inflammation of the spine and sacroiliac joints, as measured by MRI, and the association between clinical and MRI outcomes in patients with axial spondyloarthritis. 

Braun J, Baraliakos X, Hermann et al. 2017
phase 4

CIMZIA® (certolizumab pegol)

Women's Health

Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. 

Clowse ME, Förger F, Hwang C et al. 2017